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This website was developed to share information about treating autoimmune and other chronic inflammatory diseases with Inflammation Therapy.
Inflammation Therapy is based on the Persistent Pathogen Premise of Autoimmune and Inflammatory Diseases:
Intracellular bacteria interfere with the immune system by down-regulating the vitamin D receptor (VDR). The sabotaged immune system is less capable of transcribing antimicrobial peptides (AMPs) which kill pathogens. Production of 1,25(OH)2D, cytokines and endotoxins is increased in an effort to eliminate occult intracellular and extracellular pathogens. The end result is persistent low-grade inflammation, tissue damage and disease. Low 25(OH)D (vitamin D deficiency) is a marker of this inflammatory process. For details and scientific references, please read Vitamin D, Cell Wall Deficient Bacteria and the Immune System.
Inflammation Therapy is a type of immunotherapy designed to improve immune system function. The key component is Benicar (olmesartan medoxomil) which is approved by the FDA for the use of hypertension in adults and children. Benicar has been found to be a ligand of the vitamin D nuclear receptor (VDR) and is being used off-label as a VDR agonist to up-regulate production of antimicrobial peptides. This results in killing of intracellular bacteria which appear to use strategies that suppress the immune system in order to thrive within cells of the immune system. Chronic inflammation is caused by the immune system's futile attempts to eradicate the intracellular pathogens.
Immunotherapy with Benicar may also include pulsed administration of select MIC (minimum inhibitory concentration) oral antibiotics to weaken and help eradicate the intracellular pathogens. With each antibiotic dose, inflammatory symptoms (Jarisch-Herxheimer reaction) wax and wane, providing evidence of persistent infection. Changes in laboratory findings (e.g., BUN, creatinine, CRP, blood counts, liver enzymes) often point to areas of occult inflammation. A correlating treatment strategy is the avoidance of excessive sunlight exposure, foods high in vitamin D and vitamin D supplements to maintain serum 25(OH)D at a level (20-30 ng/ml) that isn't likely to suppress the immune system and inhibit bacterial elimination.
Please click on 'Inflammation Therapy' in the navigation bar (to the left), to learn more.
If you wish to enroll in our counseling program for patients on Inflammation Therapy, please email us at
"Your help to me has been extraordinary! Thank you so much. I asked my doctor if the service CIR was providing was helpful. Her response was an immediate resounding, Thank you. It's so worthwhile." Sue from St. Louis
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Updated March 28, 2014